Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination

Das Neves SP et al. demonstrated that dysfunction of the meningeal lymphatics leads to the loss of mature oligodendrocytes and subsequent demyelination in the brain. Defective meningeal lymphatics create a neuroinflammatory environment that hinders the replenishment of oligodendrocytes following a demyelinating injury. Interestingly, in patients with multiple sclerosis, a decrease in vascular endothelial growth factor C in the cerebrospinal fluid may indicate impaired meningeal lymphatic function. This research is highly relevant, as it may have therapeutic implications for autoimmune demyelinating disorders.