Microbiota has been recently emerging as an unexpectedly important partner in immune homeostasis and its disfunctions have been correlated to virtually every immunopathological condition.
This review, written by June Round (Department of Pathology, University of Utah School of Medicine) and Noah Palm (Department of Immunobiology, Yale University School of Medicine), is organized in two parts: firstly, the authors covered the experimental approaches currently used to study microbiota in animal models, focussing on the relative advantages and limitation of each method; in the second half of the review, Round and Palm analysed the relationship between microbiota dysfunctions and aberrant immune responses.
Link to the paper (only for registered users)
Link to the original source (Science Immunology website)
The image was modified from the cover of Trends in Immunology, November 2014 Volume 35, Issue 11 (link)