T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity
Sagan et al. investigated the mechanism involving the loss of tolerance in the development of demyelinating disorders mediated by AQP4 or MOG autoantibodies. Characteristically, AQP4 is expressed not only in CNS but also in other tissues otherwise MOG is restricted to CNS. In detail the Authors demonstrated that: AQP4-reactive Th17 cells from AQP4-deficient (AQP4−/−), but […]