Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology
Pham MC et al. overcoming the study of polyclonal serum in patients with myasthenia gravis (MG) by producing several monoclonal antibodies (mAb) which target the nicotinic acetylcholine receptor (AchR) reporting that: The single autoreactive clones can react with different AChR subunit The AchR mAbs can mediate the disorder by complement activation, receptor blockade and antigenic […]