CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy
Globoid cell leukodystrophy (GLD) is a fatal genetic demyelinating disorder of the central nervous system. GLS is caused by loss-of-function mutations in the galactosylceramidase (galc) gene, but several neuropathological data have suggested a relevant role of adaptive immunity and CD8+ T cells in GLD. Sutter et Al. studied the role of cytotoxic CD8+ T lymphocytes […]