MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity
O’Connor et al. demonstrated with a high-throughput assays based on the use of flow cytometry that: 1) MOGAD patient sera can cause damage on MOG-expressing cells by multiple mechanism which includes complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADCP) 2) not all sera with anti-MOG antibodies induce cytotoxicity 3) cytotoxicity is not only related to […]