Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Thomas OG et al. demonstrated T cell responses against anoctamin-2 (ANO2) occurring in over half of multiple sclerosis (MS) patients. These ANO2-specific T cells cross-react with EBV nuclear antigen 1 (EBNA1), and ANO2 immunization or ANO2-specific T cell transfer in mice leads to worsening of the MS animal model. This work is extremely important because […]