IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology
This cutting-edge article by Gianvito Masi et al. identifies a previously unrecognized pathogenic antibody isotype in a subset of patients with MuSK myasthenia gravis (MuSK MG): MuSK-specific IgA coexists with IgG4 and can modulate pathogenesis both independently and in cooperation with MuSK IgG4. Patient-derived MuSK IgA monoclonal antibodies demonstrate partial Musk agonism and potential antagonism […]