The Identity and Function of Microglia in Neurodegeneration
Microglia, the most abundant brain-resident immune cell, are specialized – highly heterogeneous tissue macrophages that control many functional and developmental features of the central nervous system (CNS). Their homeostatic population comes mostly by yolk sac precursors during embryogenesis and maintain a rather well-defined transcriptional signature that is maintained by cytokines of the brain environment (e.g. […]