PD-L1 positive astrocytes attenuate inflammatory functions of PD-1 positive microglia in models of autoimmune neuroinflammation
Astrocytes plays an important role during neuroinflammatory conditions, because depending to CNS micromilieu, can promote or inhibit several pathological processes. Linnerbauer et Al. studied the features of the astrocytes that upregulate PD-L1 in multiple sclerosis (MS) demonstrating that: During the peak of experimental autoimmune encephalomyelitis (EAE) astrocytes are the glial cells that most upregulates PD-L1. […]