Microglia necroptosis is necessary for the remyelination of central nervous system.
Lack of remyelination and microglial activation in the central nervous system (CNS) are common features of several neurodegenerative diseases (e.g. multiple sclerosis, amiotrophic lateral sclerosis, spinal cord injury). On the other end, effective regeneration of the axonal myelin sheath strongly depends on the capacity of CNS-resident microglia of undergoing a phenotypical transition during which pro-inflammatory […]