Roberta Magliozzi

Dept. of Brain Sciences,
Imperial College Faculty of Medicine
Dept. of Neurosciences, Biomedicine and Movement,
University of Verona
London | UK / Verona | Italy

Since when I started to work in 2000 in the lab of Dr. F. Aloisi my main research interest was to better understand the immunopathological mechanisms involved in multiple sclerosis and in particular in chronic inflammation. From 2004, when I started the PhD at Imperial College London under the supervision of Prof. R. Reynolds, I have paid particular attention to the inflammatory response and the role of ectopic lymphoid-like structures in the meningeal intrathecal inflammation and the association with cortical grey matter pathology and more severe disease outcome. From 2015 onwards, at the University of Verona, I have focused to translate neuroimmunological and neuropathological findings in potential new MS biomarkers of the different disease phenotypes and of MS progression. 

The aim for my future career, that will continue at Imperial College London and at the UK MS Society Tissue Bank, is to develop an independent, internationally recognised, research group interacting with numerous MS research centres worldwide, in order to investigate the detailed molecular mechanisms involved in compartmentalised inflammation and subsequent neurodegeneration in the MS brain. This will involve a focus on the use of a multi-omics approach on well characterised human brain tissue samples and validation with cell and animal systems, with the ultimate aim of identifying novel therapeutic approaches to treat progressive MS.