TNF receptors represent an important node of immune reactions, both innate and adaptive, and an important pharmacological target in the treatment of several autoimmune conditions. Their role has also been recently established in the regulation of Treg function, although the full extent and nature of the signals sprouting from the plethora of ligands that engage it is still poorly understood.
In this review, Eva S. Vanamee and Denise L. Faustman (Immunobiology department, Harvard Medical School) gathered the known literature regarding structure, function, receptor membrane clustering and transduction partners of this pivotal receptors, with some attention to their role in Treg function.